Age- and sex-specific weight gain norms to monitor antiretroviral treatment in children in low- and middle-income countries
Identifieur interne : 003201 ( Main/Exploration ); précédent : 003200; suivant : 003202Age- and sex-specific weight gain norms to monitor antiretroviral treatment in children in low- and middle-income countries
Auteurs : Marcel Yotebieng [États-Unis] ; Tammy Meyers [Afrique du Sud] ; Frieda Behets [États-Unis] ; Mary-Ann Davies [Afrique du Sud] ; Olivia Keiser [Suisse] ; Kapella Zacharia Ngonyani [Tanzanie] ; Rita E. Lyamuya [Tanzanie] ; Azar Kariminia [Australie] ; Rawiwan Hansudewechakul [Thaïlande] ; Valeriane Leroy [France] ; Sikiratou Koumakpai [Bénin] ; Jamie Newman [États-Unis] ; Annelies Van Rie [États-Unis]Source :
- AIDS (London, England) [ 0269-9370 ] ; 2015.
Descripteurs français
- KwdFr :
- Agents antiVIH (usage thérapeutique), Charge virale, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Infections à VIH (traitement médicamenteux), Modèles de hasards proportionnels, Mâle, Nourrisson, Numération des lymphocytes CD4, Pauvreté, Prise de poids, Thérapie antirétrovirale hautement active, Valeurs de référence.
- MESH :
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH.
- Charge virale, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Modèles de hasards proportionnels, Mâle, Nourrisson, Numération des lymphocytes CD4, Pauvreté, Prise de poids, Thérapie antirétrovirale hautement active, Valeurs de référence.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Anti-HIV Agents.
- drug therapy : HIV Infections.
- Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Child, Child, Preschool, Female, Humans, Infant, Male, Poverty, Proportional Hazards Models, Reference Values, Viral Load, Weight Gain.
Abstract
Viral load and CD4% are often not available in resource-limited settings for monitoring children's responses to antiretroviral treatment (ART). We aimed to construct normative curves for weight gain at six-, twelve-, eighteen-, and twenty-four-month post initiation of ART in children, and to assess the association between poor weight gain and subsequent responses to ART.
Analysis of data from HIV-infected children <10 years old from African and Asian clinics participating in the International epidemiologic Databases to Evaluate AIDS (IeDEA).
The generalized additive model for location, scale and shape was used to construct normative percentile curves for weight gain at six, twelve, eighteen, and twenty-four months following ART initiation. Cox proportional models were used to assess the association between lower percentiles (<50th) of weight gain distribution at the different time points and subsequent death, virological suppression, and virological failure.
Among 7173 children from five regions of the world, 45% were underweight at baseline. Weight gain below the 50th percentile at six-, twelve-, eighteen-, and twenty-four months of ART was associated with increased risk of death, independent of baseline characteristics. Poor weight gain was not associated with increased hazards of virological suppression or virological failure.
Monitoring weight gain on ART using age- and sex-specific normative curves specifically developed for HIV-infected children on ART is a simple, rapid, sustainable tool that can aid in the identification of children who are at increased risk of death in the first year of ART.
Url:
DOI: 10.1097/QAD.0000000000000506
PubMed: 25562494
PubMed Central: 4383257
Affiliations:
- Afrique du Sud, Australie, Bénin, France, Suisse, Tanzanie, Thaïlande, États-Unis
- Aquitaine, Canton de Berne, Caroline du Nord, Gauteng, Nouvelle-Aquitaine, Ohio
- Berne, Bordeaux, Johannesbourg
- Université de Berne, Université du Witwatersrand
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low- and middle-income countries</title><author><name sortKey="Yotebieng, Marcel" sort="Yotebieng, Marcel" uniqKey="Yotebieng M" first="Marcel" last="Yotebieng">Marcel Yotebieng</name><affiliation wicri:level="2"><nlm:aff id="A1">The Ohio State University, College of Public Health, Division of Epidemiology, Columbus, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>The Ohio State University, College of Public Health, Division of Epidemiology, Columbus</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">The University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>The University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Meyers, Tammy" sort="Meyers, Tammy" uniqKey="Meyers T" first="Tammy" last="Meyers">Tammy Meyers</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Pediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Pediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author><author><name sortKey="Behets, Frieda" sort="Behets, Frieda" uniqKey="Behets F" first="Frieda" last="Behets">Frieda Behets</name><affiliation wicri:level="2"><nlm:aff id="A4">The University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>The University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Davies, Mary Ann" sort="Davies, Mary Ann" uniqKey="Davies M" first="Mary-Ann" last="Davies">Mary-Ann Davies</name><affiliation wicri:level="1"><nlm:aff id="A5">University of Cape Town, School of Public Health and Family Medicine, Cape Town, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>University of Cape Town, School of Public Health and Family Medicine, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Keiser, Olivia" sort="Keiser, Olivia" uniqKey="Keiser O" first="Olivia" last="Keiser">Olivia Keiser</name><affiliation wicri:level="4"><nlm:aff id="A6">Institute of Social and Preventive Medicine, University of Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine, University of Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region nuts="3" type="region">Canton de Berne</region></placeName><orgName type="university">Université de Berne</orgName></affiliation></author><author><name sortKey="Ngonyani, Kapella Zacharia" sort="Ngonyani, Kapella Zacharia" uniqKey="Ngonyani K" first="Kapella Zacharia" last="Ngonyani">Kapella Zacharia Ngonyani</name><affiliation wicri:level="1"><nlm:aff id="A7">Tumbi Regional Referral Hospital, Kibaha, Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Tumbi Regional Referral Hospital, Kibaha</wicri:regionArea><wicri:noRegion>Kibaha</wicri:noRegion></affiliation></author><author><name sortKey="Lyamuya, Rita E" sort="Lyamuya, Rita E" uniqKey="Lyamuya R" first="Rita E." last="Lyamuya">Rita E. Lyamuya</name><affiliation wicri:level="1"><nlm:aff id="A8">Morogoro Regional Hospital, Morogoro, Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Morogoro Regional Hospital, Morogoro</wicri:regionArea><wicri:noRegion>Morogoro</wicri:noRegion></affiliation></author><author><name sortKey="Kariminia, Azar" sort="Kariminia, Azar" uniqKey="Kariminia A" first="Azar" last="Kariminia">Azar Kariminia</name><affiliation wicri:level="1"><nlm:aff id="A9">University of New South Wales, The Kirby Institute for infection and immunity in Society, Darlinghurst, NSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of New South Wales, The Kirby Institute for infection and immunity in Society, Darlinghurst, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Hansudewechakul, Rawiwan" sort="Hansudewechakul, Rawiwan" uniqKey="Hansudewechakul R" first="Rawiwan" last="Hansudewechakul">Rawiwan Hansudewechakul</name><affiliation wicri:level="1"><nlm:aff id="A10">Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Chiangrai Prachanukroh Hospital, Chiang Rai</wicri:regionArea><wicri:noRegion>Chiang Rai</wicri:noRegion></affiliation></author><author><name sortKey="Leroy, Valeriane" sort="Leroy, Valeriane" uniqKey="Leroy V" first="Valeriane" last="Leroy">Valeriane Leroy</name><affiliation wicri:level="3"><nlm:aff id="A11">Université Bordeaux, Institut de Santé Publique Epidémiologie et Développement, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Bordeaux, Institut de Santé Publique Epidémiologie et Développement, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Inserm, Centre Inserm U897 “Epidémiologie et Biostatistique”, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Centre Inserm U897 “Epidémiologie et Biostatistique”, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Koumakpai, Sikiratou" sort="Koumakpai, Sikiratou" uniqKey="Koumakpai S" first="Sikiratou" last="Koumakpai">Sikiratou Koumakpai</name><affiliation wicri:level="1"><nlm:aff id="A13">Centre National Hospitalier Universitaire Hubert K. Maga, Cotonou, Bénin</nlm:aff><country xml:lang="fr">Bénin</country><wicri:regionArea>Centre National Hospitalier Universitaire Hubert K. Maga, Cotonou</wicri:regionArea><wicri:noRegion>Cotonou</wicri:noRegion></affiliation></author><author><name sortKey="Newman, Jamie" sort="Newman, Jamie" uniqKey="Newman J" first="Jamie" last="Newman">Jamie Newman</name><affiliation wicri:level="2"><nlm:aff id="A14">RTI International, Biostatistics and Epidemiology, Research Triangle Park, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>RTI International, Biostatistics and Epidemiology, Research Triangle Park</wicri:cityArea></affiliation></author><author><name sortKey="Van Rie, Annelies" sort="Van Rie, Annelies" uniqKey="Van Rie A" first="Annelies" last="Van Rie">Annelies Van Rie</name><affiliation wicri:level="2"><nlm:aff id="A2">The University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>The University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill</wicri:cityArea></affiliation></author></analytic><series><title level="j">AIDS (London, England)</title><idno type="ISSN">0269-9370</idno><idno type="eISSN">1473-5571</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-HIV Agents (therapeutic use)</term><term>Antiretroviral Therapy, Highly Active</term><term>CD4 Lymphocyte Count</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>HIV Infections (drug therapy)</term><term>Humans</term><term>Infant</term><term>Male</term><term>Poverty</term><term>Proportional Hazards Models</term><term>Reference Values</term><term>Viral Load</term><term>Weight Gain</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents antiVIH (usage thérapeutique)</term><term>Charge virale</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Infections à VIH (traitement médicamenteux)</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Nourrisson</term><term>Numération des lymphocytes CD4</term><term>Pauvreté</term><term>Prise de poids</term><term>Thérapie antirétrovirale hautement active</term><term>Valeurs de référence</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Antiretroviral Therapy, Highly Active</term><term>CD4 Lymphocyte Count</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Poverty</term><term>Proportional Hazards Models</term><term>Reference Values</term><term>Viral Load</term><term>Weight Gain</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Charge virale</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Nourrisson</term><term>Numération des lymphocytes CD4</term><term>Pauvreté</term><term>Prise de poids</term><term>Thérapie antirétrovirale hautement active</term><term>Valeurs de référence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Viral load and CD4% are often not available in resource-limited settings for monitoring children's responses to antiretroviral treatment (ART). We aimed to construct normative curves for weight gain at six-, twelve-, eighteen-, and twenty-four-month post initiation of ART in children, and to assess the association between poor weight gain and subsequent responses to ART.</p></sec><sec id="S2"><title>Design</title><p id="P2">Analysis of data from HIV-infected children <10 years old from African and Asian clinics participating in the International epidemiologic Databases to Evaluate AIDS (IeDEA).</p></sec><sec id="S3"><title>Methods</title><p id="P3">The generalized additive model for location, scale and shape was used to construct normative percentile curves for weight gain at six, twelve, eighteen, and twenty-four months following ART initiation. Cox proportional models were used to assess the association between lower percentiles (<50<sup>th</sup>) of weight gain distribution at the different time points and subsequent death, virological suppression, and virological failure.</p></sec><sec id="S4"><title>Results</title><p id="P4">Among 7173 children from five regions of the world, 45% were underweight at baseline. Weight gain below the 50<sup>th</sup> percentile at six-, twelve-, eighteen-, and twenty-four months of ART was associated with increased risk of death, independent of baseline characteristics. Poor weight gain was not associated with increased hazards of virological suppression or virological failure.</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">Monitoring weight gain on ART using age- and sex-specific normative curves specifically developed for HIV-infected children on ART is a simple, rapid, sustainable tool that can aid in the identification of children who are at increased risk of death in the first year of ART.</p></sec></div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Australie</li><li>Bénin</li><li>France</li><li>Suisse</li><li>Tanzanie</li><li>Thaïlande</li><li>États-Unis</li></country><region><li>Aquitaine</li><li>Canton de Berne</li><li>Caroline du Nord</li><li>Gauteng</li><li>Nouvelle-Aquitaine</li><li>Ohio</li></region><settlement><li>Berne</li><li>Bordeaux</li><li>Johannesbourg</li></settlement><orgName><li>Université de Berne</li><li>Université du Witwatersrand</li></orgName></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Yotebieng, Marcel" sort="Yotebieng, Marcel" uniqKey="Yotebieng M" first="Marcel" last="Yotebieng">Marcel Yotebieng</name></region><name sortKey="Behets, Frieda" sort="Behets, Frieda" uniqKey="Behets F" first="Frieda" last="Behets">Frieda Behets</name><name sortKey="Newman, Jamie" sort="Newman, Jamie" uniqKey="Newman J" first="Jamie" last="Newman">Jamie Newman</name><name sortKey="Van Rie, Annelies" sort="Van Rie, Annelies" uniqKey="Van Rie A" first="Annelies" last="Van Rie">Annelies Van Rie</name><name sortKey="Yotebieng, Marcel" sort="Yotebieng, Marcel" uniqKey="Yotebieng M" first="Marcel" last="Yotebieng">Marcel Yotebieng</name></country><country name="Afrique du Sud"><region name="Gauteng"><name sortKey="Meyers, Tammy" sort="Meyers, Tammy" uniqKey="Meyers T" first="Tammy" last="Meyers">Tammy Meyers</name></region><name sortKey="Davies, Mary Ann" sort="Davies, Mary Ann" uniqKey="Davies M" first="Mary-Ann" last="Davies">Mary-Ann Davies</name></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Keiser, Olivia" sort="Keiser, Olivia" uniqKey="Keiser O" first="Olivia" last="Keiser">Olivia Keiser</name></region></country><country name="Tanzanie"><noRegion><name sortKey="Ngonyani, Kapella Zacharia" sort="Ngonyani, Kapella Zacharia" uniqKey="Ngonyani K" first="Kapella Zacharia" last="Ngonyani">Kapella Zacharia Ngonyani</name></noRegion><name sortKey="Lyamuya, Rita E" sort="Lyamuya, Rita E" uniqKey="Lyamuya R" first="Rita E." last="Lyamuya">Rita E. Lyamuya</name></country><country name="Australie"><noRegion><name sortKey="Kariminia, Azar" sort="Kariminia, Azar" uniqKey="Kariminia A" first="Azar" last="Kariminia">Azar Kariminia</name></noRegion></country><country name="Thaïlande"><noRegion><name sortKey="Hansudewechakul, Rawiwan" sort="Hansudewechakul, Rawiwan" uniqKey="Hansudewechakul R" first="Rawiwan" last="Hansudewechakul">Rawiwan Hansudewechakul</name></noRegion></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Leroy, Valeriane" sort="Leroy, Valeriane" uniqKey="Leroy V" first="Valeriane" last="Leroy">Valeriane Leroy</name></region><name sortKey="Leroy, Valeriane" sort="Leroy, Valeriane" uniqKey="Leroy V" first="Valeriane" last="Leroy">Valeriane Leroy</name></country><country name="Bénin"><noRegion><name sortKey="Koumakpai, Sikiratou" sort="Koumakpai, Sikiratou" uniqKey="Koumakpai S" first="Sikiratou" last="Koumakpai">Sikiratou Koumakpai</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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